Tuberculosis illness (TB), brought on by Mycobacterium tuberculosis, is a serious public well being concern in Thailand. The excessive prevalence of recent Beijing (Lineage 2.2.1) strains has been related to multi- and extensively-drug resistant infections (MDR-, XDR-TB), complicating illness management. The affect of rarer proto-Beijing (L2.1) strains is much less clear. In our research of thirty-seven L2.1 scientific isolates spanning 13 years, we discovered a excessive prevalence of XDR-TB circumstances (32.4%).

With ≤ 12 pairwise SNP distances, 43.2% of L2.1 sufferers belong to MDR-TB or XDR-TB transmission clusters suggesting a excessive degree of clonal growth throughout 4 Thai provinces. All XDR-TB (100%) have been possible attributable to transmission quite than insufficient remedy. We discovered a 47 mutation signature and a partial deletion of the fadD14 gene within the circulating XDR-TB cluster, which can be utilized for surveillance of this uncommon and resilient M. tuberculosis strain-type that’s inflicting rising well being burden. We additionally detected three novel deletion positions, a deletion of 1,285 bp inside desA3 (Rv3230c), giant deletions within the plcB, plcA, and ppe38 gene which can play a job within the virulence, pathogenesis or evolution of the L2.1 strain-type.

The Veterans Affairs Precision Oncology Information Repository, a Medical, Genomic, and Imaging Analysis Database

The Veterans Affairs Precision Oncology Information Repository (VA-PODR) is a big, nationwide repository of de-identified knowledge on sufferers recognized with most cancers on the Division of Veterans Affairs (VA). Information embrace longitudinal scientific knowledge from the VA’s nationwide digital well being file system and the VA Central Most cancers Registry, focused tumor sequencing knowledge, and medical imaging knowledge together with computed tomography (CT) scans and pathology slides.

A subset of the repository is out there on the Genomic Information Commons (GDC) and The Most cancers Imaging Archive (TCIA), and the total repository is out there by means of the Veterans Precision Oncology Information Commons (VPODC). By releasing this de-identified dataset, we goal to advance Veterans’ well being care by means of enabling translational analysis on the Veteran inhabitants by all kinds of researchers.

Uncovering Efficient Explanations for Interactive Genomic Information Evaluation

Higher instruments are wanted to allow researchers to shortly establish and discover efficient and interpretable feature-based explanations for discriminating multi-class genomic datasets, e.g., wholesome versus diseased samples. We develop an interactive exploration instrument, GENVISAGE, which quickly discovers essentially the most discriminative function pairs that separate two courses of genomic objects after which shows the corresponding visualizations.
Since shortly discovering prime function pairs is computationally difficult, particularly for big numbers of objects and options, we suggest a collection of optimizations to make GENVISAGE responsive at scale and reveal that our optimizations result in a 400× speedup over aggressive baselines for a number of organic datasets. We apply our speedy and interpretable instrument to establish literature-supported pairs of genes whose transcriptomic responses considerably discriminate a number of chemotherapy drug therapies. With its generalizable optimizations and framework, GENVISAGE opens up real-time feature-based clarification era to knowledge from large sequencing efforts, in addition to many different scientific domains.

Genomics of Human Fibrotic Illnesses: Disordered Wound Therapeutic Response

Fibrotic illness, which is implicated in virtually half of all deaths worldwide, is the results of an uncontrolled wound therapeutic response to harm wherein tissue is changed by deposition of extra extracellular matrix, resulting in fibrosis and lack of organ operate. A plethora of genome-wide affiliation research, microarrays, exome sequencing research, DNA methylation arrays, next-generation sequencing, and profiling of noncoding RNAs have been carried out in patient-derived fibrotic tissue, with the shared aim of using genomics to establish the transcriptional networks and organic pathways underlying the event of fibrotic illnesses.
On this evaluate, we talk about fibrosing issues of the pores and skin, liver, kidney, lung, and coronary heart, systematically (1) characterizing the preliminary acute harm that drives unresolved irritation, (2) figuring out genomic research which have outlined the pathologic gene modifications resulting in extra matrix deposition and fibrogenesis, and (3) summarizing therapies concentrating on pro-fibrotic genes and networks recognized within the genomic research. In the end, profitable bench-to-bedside translation of observations from genomic research will end result within the growth of novel anti-fibrotic therapeutics that enhance practical high quality of life for sufferers and reduce mortality from fibrotic illnesses.
Genomic evidence supporting the clonal expansion of extensively drug resistant tuberculosis bacteria belonging to a rare Proto - Beijing genotype

Genomic choice for heterobothriosis resistance concurrent with physique measurement within the tiger pufferfish, Takifugu rubripes

Parasite resistance traits in aquaculture species typically have average heritability, indicating the potential for genetic enhancements by selective breeding. Nonetheless, parasite resistance is commonly synonymous with an undesirable unfavourable correlation with physique measurement. On this research, we first examined the feasibility of genomic choice (GS) on resistance to heterobothriosis, brought on by the monogenean parasite Heterobothrium okamotoi, which results in enormous financial losses in aquaculture of the tiger pufferfish Takifugu rubripes.
Then, utilizing a simulation research, we examined the potential for simultaneous enchancment of parasite resistance, assessed by parasite counts on host fish (HC), and commonplace size (SL). Every trait confirmed average heritability (square-root remodeled HC: h2 = 0.308 ± 0.123, S.E.; SL: h2 = 0.405 ± 0.131). The predictive skills of genomic prediction amongst 12 fashions, together with genomic Finest Linear Unbiased Predictor (GBLUP), Bayesian regressions, and machine studying procedures, have been additionally average for each remodeled HC (0.248‒0.344) and SL (0.340‒0.481).

Recombinant Neisseria meningitidis serogroup B / serotype 15 Major outer membrane protein P.IB (porB)

RPC20457-100ug 100ug
EUR 721.6

Recombinant Neisseria meningitidis serogroup B / serotype 15 Major outer membrane protein P.IB (porB)

RPC20457-1mg 1mg
EUR 2884.7

Recombinant Neisseria meningitidis serogroup B / serotype 15 Major outer membrane protein P.IB (porB)

RPC20457-20ug 20ug
EUR 448.1

Neisseria meningitidis (N. meningitidis) Antibody

abx411508-1ml 1 ml
EUR 610.8

Neisseria meningitidis (N. meningitidis) Antibody

abx023104-400l 400 µl Ask for price

Neisseria meningitidis (N. meningitidis) Antibody

abx023104-80l 80 µl
EUR 1012.5

Neisseria meningitidis (N. meningitidis) Antibody

abx375004-96tests 96 tests
EUR 225

Neisseria meningitidis (N. meningitidis) Antibody

abx411508-2ml 2 ml
EUR 425

Neisseria meningitidis

Oneq-H421-OneqH421100D Oneq-H421-100D
EUR 515

Neisseria meningitidis

Oneq-H421-OneqH421150D Oneq-H421-150D
EUR 594

Neisseria meningitidis

Oneq-H421-OneqH42150D Oneq-H421-50D
EUR 413

Neisseria meningitidis

PCR-H421-PCRH42148D PCR-H421-48D
EUR 230

Neisseria meningitidis

PCR-H421-PCRH42196D PCR-H421-96D
EUR 312

Neisseria meningitidis (N. meningitidis) Antibody (FITC)

abx023103-400l 400 µl Ask for price

Neisseria meningitidis (N. meningitidis) Antibody (FITC)

abx023103-80l 80 µl
EUR 1150

Neisseria meningitidis antibody

20-NR09 1 mg
EUR 105
Description: Rabbit polyclonal Neisseria meningitidis antibody

Neisseria meningitidis Antibody

GWB-38CF28 1 ml Ask for price

Neisseria meningitidis Antibody

GWB-463190 1 ml Ask for price

Neisseria Meningitidis Antibody

GWB-4B03CA 1 ml Ask for price

Neisseria meningitidis Antibody

GWB-612F12 1 ml Ask for price

Neisseria meningitidis Antibody

GWB-DE2D90 1 ml Ask for price

Neisseria meningitidis Antibody

GWB-D5486E 0.1 ml Ask for price

Neisseria meningitidis PCR kit

PCR-H421-48D 50T
EUR 543.6

Neisseria meningitidis PCR kit

PCR-H421-96D 100T
EUR 686.4

Neisseria meningitidis serogroup C Quinolinate synthase A (nadA)

1-CSB-EP429373NEW
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Description: Recombinant Neisseria meningitidis serogroup C Quinolinate synthase A(nadA) expressed in E.coli

Neisseria meningitidis serogroup B Quinolinate synthase A (nadA)

1-CSB-EP878213NGG
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Description: Recombinant Neisseria meningitidis serogroup B Quinolinate synthase A(nadA) expressed in E.coli

PX405 Neisseria meningitidis Cas9

PVT10908 2 ug
EUR 319.2

Neisseria meningitidis RT PCR kit

RTq-H421-100D 100T
EUR 860.4

Neisseria meningitidis RT PCR kit

RTq-H421-150D 150T
EUR 969.6

Neisseria meningitidis RT PCR kit

RTq-H421-50D 50T
EUR 717.6

Neisseria meningitidis Antibody (FITC)

GWB-239FBA 1 ml Ask for price

Neisseria meningitidis LPDA Antibody

abx018300-1ml 1 ml
EUR 300

Neisseria meningitidis LPDA Antibody

abx018301-1ml 1 ml
EUR 300

Neisseria meningitidis GNA2132 Antibody

abx018266-1ml 1 ml
EUR 300

Neisseria meningitidis GNA2132 Antibody

abx018267-1ml 1 ml
EUR 300

Neisseria meningitidis GNA2132 Antibody

abx018268-1ml 1 ml
EUR 300

Recombinant Neisseria meningitidis serogroup C Quinolinate synthase A (nadA)

CSB-EP429373NEW 3538 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Quinolinate synthase A (nadA)

RPC25624-100ug 100ug
EUR 721.6

Recombinant Neisseria meningitidis serogroup B Quinolinate synthase A (nadA)

RPC25624-1mg 1mg
EUR 2884.7

Recombinant Neisseria meningitidis serogroup B Quinolinate synthase A (nadA)

RPC25624-20ug 20ug
EUR 448.1

Neisseria meningitidis One-Step PCR kit

Oneq-H421-100D 100T
EUR 1039.2

Neisseria meningitidis One-Step PCR kit

Oneq-H421-150D 150T
EUR 1177.2

Neisseria meningitidis One-Step PCR kit

Oneq-H421-50D 50T
EUR 861.6

Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

1-CSB-EP326992NBK
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Description: Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB(porB) expressed in E.coli

Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

1-CSB-EP329012NBK
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Description: Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB(porB) expressed in E.coli

Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

1-CSB-EP333550NGG
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Description: Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB(porB) expressed in E.coli

Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

1-CSB-EP335569NBK
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Description: Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB(porB) expressed in E.coli

Neisseria meningitidis serogroup B Major outer membrane protein P.IA (porA)

1-CSB-EP320687NGG
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Description: Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IA(porA) expressed in E.coli

genesig Easy kit for all Neisseria meningitidis

Z-Path-N.meningitidis-EASY 50 tests
EUR 410
Description: N.meningitidis

Neisseria meningitidis serogroup B Penicillin-binding protein 1A (mrcA)

1-CSB-EP363014NGG
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Description: Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A(mrcA),partial expressed in E.coli

Neisseria meningitidis serogroup B Transferrin-binding protein 1 (tbp1)

1-CSB-EP881449NGG
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Description: Recombinant Neisseria meningitidis serogroup B Transferrin-binding protein 1(tbp1),partial expressed in E.coli

Recombinant Neisseria meningitidis serogroup B Quinolinate synthase (nadA)

CSB-EP878213NGG 4661 mg Ask for price

Neisseria meningitidis antigen Orf1 / FrpD Antibody

abx140046-01mg 0.1 mg
EUR 510

Neisseria meningitidis antigen Orf1 / FrpD Antibody

abx140046-100g 100 µg
EUR 350

ViPrimePLUS Neisseria meningitidis qPCR Kit, 150rxns

QM2046 each Ask for price

OPCA05126-1MG - MRCA Recombinant Protein (Neisseria meningitidis serogroup B)

OPCA05126-1MG 1mg
EUR 1977

OPCA05126-20UG - MRCA Recombinant Protein (Neisseria meningitidis serogroup B)

OPCA05126-20UG 20ug
EUR 400

OPCA05126-100UG - MRCA Recombinant Protein (Neisseria meningitidis serogroup B)

OPCA05126-100UG 100ug
EUR 586

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

CSB-EP326992NBK 2932 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

CSB-EP329012NBK 2960 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

CSB-EP333550NGG 3012 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

CSB-EP335569NBK 3038 mg Ask for price

Recombinant Neisseria meningitidis serogroup B DNA-binding protein HU-beta (hupB)

CSB-EP350724NGG 7114 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IA (porA)

CSB-EP320687NGG 2809 mg Ask for price

Recombinant Neisseria meningitidis serogroup B DNA-binding protein HU-beta (hupB)

RPC27653-100ug 100ug
EUR 801.9

Recombinant Neisseria meningitidis serogroup B DNA-binding protein HU-beta (hupB)

RPC27653-1mg 1mg
EUR 2885.2

Recombinant Neisseria meningitidis serogroup B DNA-binding protein HU-beta (hupB)

RPC27653-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28244-100ug 100ug
EUR 765.5

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28244-1mg 1mg
EUR 2959.2

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28244-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28248-100ug 100ug
EUR 765.5

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28248-1mg 1mg
EUR 2959.2

Recombinant Neisseria meningitidis serogroup B Major outer membrane protein P.IB (porB)

RPC28248-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit beta (ihfB)

CSB-EP357958NGG 7116 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit alpha (ihfA)

CSB-EP351432NGG 7115 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit alpha (ihfA)

RPC27654-100ug 100ug
EUR 801.9

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit alpha (ihfA)

RPC27654-1mg 1mg
EUR 2885.2

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit alpha (ihfA)

RPC27654-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit beta (ihfB)

RPC27664-100ug 100ug
EUR 801.9

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit beta (ihfB)

RPC27664-1mg 1mg
EUR 2885.2

Recombinant Neisseria meningitidis serogroup B Integration host factor subunit beta (ihfB)

RPC27664-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A (mrcA), partial

CSB-EP363014NGG 3414 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Transferrin-binding protein 1 (tbp1), partial

CSB-EP881449NGG 4703 mg Ask for price

Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A(mrcA),partial

AP77136 1mg
EUR 2826

Recombinant Neisseria meningitidis serogroup B Transferrin-binding protein 1 (tbp1) ,partial

RPC25726-100ug 100ug
EUR 721.6

Recombinant Neisseria meningitidis serogroup B Transferrin-binding protein 1 (tbp1) ,partial

RPC25726-1mg 1mg
EUR 2884.7

Recombinant Neisseria meningitidis serogroup B Transferrin-binding protein 1 (tbp1) ,partial

RPC25726-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A (mrcA) ,partial

RPC20531-100ug 100ug
EUR 721.6

Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A (mrcA) ,partial

RPC20531-1mg 1mg
EUR 2884.7

Recombinant Neisseria meningitidis serogroup B Penicillin-binding protein 1A (mrcA) ,partial

RPC20531-20ug 20ug
EUR 448.1

Recombinant Neisseria meningitidis FrpA/C-binding lipoprotein (frpD_3)

CSB-EP5165NBJ 11901 mg Ask for price

Neisseria meningitidis (all antigens) rabbit polyclonal antibody, FITC

BP1051F 1 ml Ask for price

Neisseria meningitidis (all antigens) rabbit polyclonal antibody, Ig Fraction

BP1051 1 ml Ask for price

OPCA04645-1MG - Major outer membrane protein P.IB Recombinant Protein (Neisseria meningitidis)

OPCA04645-1MG 1mg
EUR 1977

OPCA04645-20UG - Major outer membrane protein P.IB Recombinant Protein (Neisseria meningitidis)

OPCA04645-20UG 20ug
EUR 400

OPCA04645-100UG - Major outer membrane protein P.IB Recombinant Protein (Neisseria meningitidis)

OPCA04645-100UG 100ug
EUR 586

Recombinant Neisseria meningitidis serogroup C Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)

CSB-EP434696NEW 7978 mg Ask for price

Recombinant Neisseria meningitidis serogroup C Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)

RPC27696-100ug 100ug
EUR 801.9

Recombinant Neisseria meningitidis serogroup C Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)

RPC27696-1mg 1mg
EUR 2885.2

Recombinant Neisseria meningitidis serogroup C Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)

RPC27696-20ug 20ug
EUR 448.1

Rabbit polyclonal antibody for Neisseria meningitids

6114 1 ml
EUR 386.26
Description: This is HRP conjugated rabbit polyclonal antibody against Neisseria meningitids all antigens for WB, ELISA.

Rabbit polyclonal antibody for Neisseria meningitids

6121 1 ml
EUR 340.57
Description: This is rabbit polyclonal antibody against Neisseria meningitids all antigens for WB, ELISA.

Rabbit polyclonal antibody for Neisseria meningitids

6123 1 ml
EUR 360.16
Description: This is FITC conjugated rabbit polyclonal antibody against Neisseria meningitids all antigens for WB, ELISA.

Rabbit polyclonal antibody for Neisseria meningitids

6127 1 ml
EUR 360.16
Description: This is Biotin conjugated rabbit polyclonal antibody against Neisseria meningitids all antigens for WB, ELISA.

Rabbit Anti-Neisseria meningitidis Polyclonal Antibody

DPAB0209 1 ml
EUR 937.2

N. Meningitidis Antibody

abx023104-1ml 1 ml
EUR 718.8

N. Meningitidis Antibody (FITC)

abx023103-1ml 1 ml
EUR 718.8

Human Meningitis B neisserial adhesin A (MenB Nad A) antibody positive control serum

MBNA21-HPC 1 ml
EUR 270

Anti-Orf1 (N. meningitidis) Purified

11-489-C025 0.025 mg
EUR 99

Anti-Orf1 (N. meningitidis) Purified

11-489-C100 0.1 mg
EUR 198

Human Meningitis B neisserial adhesin A (MenB Nad A) antibody negative control serum serum

MBNA21-HNC 1 ml
EUR 270

Recombinant Meningitis B Neisserial adhesin A (MenB Nad A) protein control for western blot

MBNA21-C 100 ul
EUR 343.2

Recombinant (E.coli) Meningitis B Neisserial adhesin A (MenB NadA) protein (His-tag, 36 kDa)

MBNA25-R-10 10 ug
EUR 416.4

Rabbit Anti-N. meningitidis Orf1 Polyclonal antibody

DPAB-CS23052 100 μg
EUR 720
Description: Rabbit

Mouse Anti-N. meningitidis Monoclonal antibody, clone 7282

DMAB-CS23166 100 μg
EUR 680
Description: Mouse

Recombinant (E.coli) Meningitis B Neisserial Heparin-Binding Antigen (MenB NHBA) (His-tag, 43 kDa.)

MBNH35-R-10 10 ug
EUR 416.4

Human Meningitis B neisserial heparin-binding antigen (MenB NHBA) antibody negative control serum

MBNH31-HNC 1 ml
EUR 270

Human Meningitis B neisserial heparin-binding antigen (MenB NHBA) antibody positive control serum

MBNH31-HPC 1 ml
EUR 270

Recombinant Meningitis B Neisserial Heparin-Binding Antigen (MenB NHBA) protein control for western blot

MBNH31-C 100 ul
EUR 343.2

genesig Real-time PCR detection kit for N.meningitidis

Z-Path-N-meningitidis 150 tests
EUR 808
Description: N.meningitidis

genesig Std Real-time PCR detection kit for N.meningitidis

Z-Path-N-meningitidis-std 150 tests
EUR 602
Description: N.meningitidis

Neisseria sp.

Oneq-H422-OneqH422100D Oneq-H422-100D
EUR 515
These outcomes confirmed the feasibility of GS for this trait. Though an undesirable genetic correlation was steered between remodeled HC and SL (rg = 0.228), the simulation research steered the specified good points index may help obtain simultaneous genetic enhancements in each traits.